Publications

1.       Xu R, Yallowtiz AR, Qin A, Shin DY, Kim JM, Debnath S, Dong H, Zhang C, Wu ZH, Lalani S, Li N, Liu YF, Poulos MG, Wach A, Zhang BH, Butler JM, Shim JH, Glimcher LH, Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nature Medicine. (In Press)

2.       Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB**. c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo. J Bone Miner Res. 2017 May 31.

3.       Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017 Feb 20;8:14570.

4.       Poulos MG, Ramalingam P, Gutkin MC, Kleppe M, Ginsberg M, Crowley MJ, Elemento O, Levine RL, Rafii S, Kitajewski J, Greenblatt MB, Shim JH, Butler JM. Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis. Nat Commun. 2016 Dec 21;7:13829.

5.       Greenblatt MB, Tsai JN, Wein MN. Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2017 Feb;63(2):464-474.

6.    Sargent JL, Li Z, Aliprantis AO, Greenblatt M, Lemaire R, Wu MH, Wei J, Taroni J, Harris A, Long KB, Burgwin C, Artlett CM, Blankenhorn EP, Lafyatis R, Varga J, Clark SH, Whitfield ML. Interspecies comparative genomics identifies optimal mouse models of systemic sclerosis. Arthritis Rheumatol. 2016 Mar 4.

7.    Greenblatt MB**, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH. MEKK2 mediates an alternative pathway for activation of β-catenin that promotes bone formation. Proc Natl Acad Sci U S A. 2016 Feb 16.

8.    Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao CC, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. CHMP5 Dampens NF-κB Activity in Osteoclasts to Regulate Systemic Bone Turnover. J Exp Med 2015 Jul 27;212(8):1283-301.

9.    Greenblatt MB, Nowak JA, Quade CC, Tanasijevic M, Lindeman NI, Jarolim P. Impact of a prospective review program for reference laboratory testing requests. Am J of Clin Pathol. 2015 May; 143(5): 627-34.

10. Greenblatt MB**, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH**. p38α MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 2;290(1):284-95.

11. Greenblatt MB, Torre M, Means J, Tanasijevic M, Pedulla LV, Bunnell CA, Conrad MJ, Jarolim P. Use of potassium levels as a quality-of-service metric for phlebotomists detects systematic preanalytical biases and facilitates their correction. Clin Chem. 2014 Nov;60(11):1453-5.

12. Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature. 2014 Apr 3;508(7494):103-7.

13. Greenblatt MB, Ritter SY, Wright J, Tsang K, Hu D, Glimcher LH, Aliprantis AO. NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19914-9.

14. Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E, Lee KY. S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol. 2014 Feb;34(3):510-21.

15. Shim JH*, Greenblatt MB*, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep 3;123(9):4010-22.

16. Zou W, Greenblatt MB, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi SP, Baron R, Glimcher LH, Jones DC. The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med. 2013 Aug 26;210(9):1793-806.

17. Greenblatt MB, Shim JH. Osteoimmunology: A Brief Introduction. Immune Netw. 2013 Aug;13(4):111-115.

18. Greenblatt MB, Shim JH, Glimcher LH. Mitogen-Activated Protein Kinase Pathways in Osteoblasts. Annu Rev Cell Dev Biol. 2013 May 31.

19. Greenblatt MB, Aliprantis AO. The immune pathogenesis of scleroderma: context is everything. Curr Rheumatol Rep. 2013 Jan;15(1):297.

20. Greenblatt MB, Shim JH, Zou WG, Glimcher LH. A TAK1/p38 Signaling Axis Regulates RUNX2 Activity and Osteoblast Functions. In: Choi YW, editor. Osteoimmunology: Interactions of the Immune and Skeletal Systems. New York: Springer New York; 2013. p.49-56.

21. Greenblatt MB, Vbranac V, Tivey T, Tsang K, Tager AM, Aliprantis AO. Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. PLoS One. 2012;7(9):e44664.

22. Greenblatt MB*, Sargent JL*, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML , Aliprantis AO. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012 Mar;180(3):1080-94.

23. Shim JH*, Greenblatt MB*, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest. 2012 Jan 3;122(1):91-106.

24. Zou W*, Greenblatt MB*, Shim JH, Kant S,  Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D,  Glimcher LH. MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov 1;121(11):4383-92.

25. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59.

26. Greenblatt MB*, Shim JH*, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul 1;120(7):2457-73.

27. Greenblatt MB, Aliprantis A, Hu B, Glimcher LH. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med. 2010 May 10;207(5):923-31.

28. Greenblatt MB, Shim JH, Glimcher LH. TAK1 mediates BMP signaling in cartilage. Ann N Y Acad Sci. 2010 Mar;1192(1):385-90.

29. Shim JH*, Greenblatt MB*, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signaling in cartilage. EMBO J. 2009 Jul 22;28(14):2028-41. 

30. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5; 303(5663):1522-6.